Pregelatinized starch is an excipient of natural origin and hence is non toxic and hypoallergenic to human patients. The functionality of PGS depends on a large extent on the source of the starch from which it is converted from. The aim of the present work was to compare the physical, chemical properties and the functional utility of PGS from four different sources. The functionality was checked as diluent, binder and disintegrant in immediate release tablets of Aceclofenac, capsules or Fluoxetine HCl and Orally disintegrating tablets of Aripiprazole. In conclusion it can be said that the above study demonstrates that sources of PGS may affect the functionality of the excipient. Hence identifying the correct source of the PGS is critical in developing a successful formulation based on the critical quality attributes required.