In Ethiopia many medicinal plants are used for the treatment of malaria including Dodonaea angustifolia seed without considering their side effects. The side effect of those medicinal plants can be evaluated by the use of the chronic treatment or acute treatment. In such a case laboratory animals were administered with the crude extracts of the plant through the oral route using oral gavage for at least six weeks at different doses. At the end of the experiment, all mice under treatment were sacrificed after blood collection for hematological and biochemical analysis and liver and kidney sections were randomly taken for tissue processing. The results of hematological and biochemical analysis as well as the microscopic examinations of the liver and kidney sections were compared with control groups.