The prevailing higher prices of inorganic fertilizer along with low nutrient value and shortage of organic fertilizers like Farm Yard Manure (FYM) has become a main problem in managing soil fertility problems in Tigray. So, integrated use of organic and inorganic fertilizer help to overcome problems with the sole application. Based on this, a field experiment was conducted to study the effect of integrated use of FYM and Urea fertilizers on yield of irrigated tomato (Lycopersicon esculentum Mill), soil fertility improvements and socio-economic acceptability. FYM and Urea was integrated in different proportions to supply 60Kgha-1 of Nitrogen (N) from both sources at different ratios.5 different combinations along with one control were used as treatments.The experiment was arranged in RCB Design with 4 replications. The results of the experiment showed that integrated use of FYM and Urea significantly increased the major soil chemical properties (p< 0.05), marketable yield (375.4Qlha-1) and economic profit. The Perception of the respondent farmers also indicates that 44.4% use an integration of both nutrient sources for better tomato productivity.