The use of anticancer agents as part of the treatment
strategy has greatly improved the overall prognosis
of cancer. In clinical practice, chemotherapy for
cancer often requires a combination of drugs and
therefore understanding the clinical pharmacology of
anticancer drugs is imperative for achieving optimal
benefits from use of these agents.
The aim of this thesis was to investigate the
biochemical and cytotoxic effects of naturally
occurring compounds, such as resveratrol, resveratrol
analogs, piceatannol, gallic acid, Avemar, and heavy
water alone and/or in combination with clinically
established anticancer agents such as
arabinofuranosylcytosine and gemcitabine.
The effects of these drugs were examined in human and
murine leukemia cells as well as in human pancreatic
tumor cell lines.
We hope that our experiments may help to elucidate
the biochemical pathways involved in the drug
combinations applied and provide the basis for
further in vivo studies in order to develop new
strategies for the treatment of human malignancies.