The extant literature indicates a modestly positive association between religion and psychological adjustment. However, the role that spirituality plays in wellbeing relative to both high and low levels of religiosity is not well known. The purpose of this study was to examine the extent to which daily spiritual experiences mediate the association between perceived stress and symptoms of anxiety / depression, and to further examine the extent to which religious commitment moderates this relationship. In this study, spirituality acted as a partial mediator between perceived stress and psychological adjustment. In addition, both spirituality and religiosity acted as moderators between stress and psychological symptoms. However, religiosity did not act as a significant mediator between stress and psychological adjustment. In addition, religiosity did not seem to significantly moderate the mediating effects of spirituality. Overall, this study confirmed the role of both religiosity and spirituality as effective coping resources. Therefore, mental health professionals should acknowledge religious and spiritual coping as personal resiliency factors.