Newcastle disease is a highly contagious viral disease affecting many domestic and wild avian species that have severe impact on poultry industry.It can also be transmitted to humans that cause conjunctivitis and flu like symptoms. Effective vaccination of flock is the means to control this disease. This book was to investigate persistence of maternal antibody as well as the comparative efficacy of Avinew and BCRDV vaccines against Newcastle disease in chicks. Birds of groups A and B were primarily and secondarily vaccinated with Avinew and BCRDV respectively at the age of day 3 and 20. Sera samples were obtained from 10 randomly selected birds on each occasion of day 1, 10, 17, 27, 30, 34 and 44 of age of birds. Birds of group C were maintained as unvaccinated control for the determination of existence of maternal antibody. Thus it was indicated that performance of Avinew in respect of elucidation of HI antibody was comparatively better than that of BCRDV and maternal antibody against NDV in chicks persisted to a minimal until the age of day 27 and none at day 30 or 34. This analysis will be useful to professionals working for poultry industry, researcher and vaccine manufacturer.