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EGFR expression and the role of Gefitinib in Oral cavity lesions


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Oral Cavity cancer is the 10th most common malignancy globally. EGFR is a glycoprotein encoded by a gene located on chromosome 7p12. Stimulation of EGFR will activate an intracellular signalling pathway, leading to the inhibition of apoptosis, activation of cell proliferation and angiogenesis, as well as an increase in metastatic spread potential. In premalignant lesions EGFR can be considered as an early marker of a cell proliferation on cell differentiation as well as early marker of epithelial dysplasia and onset of cancer in oral premaligant lesions. Hence cancers of oral cavity can be prevented and progress of carcinogenisis may be stopped at a early stage. EGFR evaluation can be used as a Screening tool in premalignant lesions to determine its malignant potential. In Malignant it has been seen that there is better response to treatment when EGFR Inhibitor Gefitinib was combined to the standard regimen of CCRT in Locally advanced Oral cavity malignant lesions.

Product Specifications
SKU :COC84371
AuthorUmesh Velu,Awadesh Kumar Dixit and Shambunath Prasad
Number of Pages56
Publishing Year2013-03-25T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00