Over the last few years, biomedical engineering had a rapid progress on fabricating more precise and accurate biosensors, joining these results with a decrease in analysis costs. Electrochemiluminescence is a reliable and low-cost technique for the sensing of biomolecules, such as DNA and proteins. The scope of this book is to engineer this powerful method in order to design more sensitive biosensors. After an overview about the most common electrochemical techniques, the author presents a novel approach that involves carbon nanotubes to increase the sensitivity. This approach leads to a future miniaturization in order to build an integrated biosensor. This book could be useful to analyze thoroughly electrochemiluminescence aspects and to get new ideas for developing next generation biosensors.