Central nervous system (CNS) drugs are of cardinal importance in day-to-day life to remove pain from conditions such as headache (including migraine), muscle aches, menstrual cramps,arthritis, backache, toothaches, colds and sinus infections. However, an overdose of these drugs is toxic in nature. Hence, their determination in trace quantities is of great importance. Nanomaterials due to their good electrical conductivity and a high aspect ratio have triggered a new genre for the development of novel electrode materials. In this respect, studies dealing with fabrication of electrochemical sensors in the form of chemically modified electrodes (CMEs) for determination of CNS drugs are of tremendous importance to clinical as well as pharmaceutical industries. The goal of the present investigation is basic cum applied in nature and it aims at the development of CMEs for CNS drugs viz. acetaminophen, aspirin, caffeine, venlafaxine, desvenlafaxine, tramadol,dopamine, L-dopa, epinephrine, norepinephrine, imipramine, trimipramine and desipramine. In addition, two pesticides viz., methyl and ethyl parathion have been included in the present work since they directly affect the CNS.