Effluent from the bulk drug industry contains toxic and bio-refractory compounds plus the effluent quality usually cannot comply with the effluent discharge standards after conventional biological treatment processes. Electrochemical oxidation has come up as a promising technology for the treatment of Effluents containing bio-refractory organics. The study is performed for the advance treatment of bulk drug effluent through electrochemical oxidation and biological treatment technologies. The BDD electrode used in this technology has high over-potential for oxygen evolution and chemical stability. So it is an effective means to electrochemically decompose bio-refractory COD ammonical nitrogen, heavy metals, toxic compounds etc. through direct and indirect oxidation from the wastewater. For this reason, oxidative electrochemical technologies and have reached a promising stage of development Intensive research has been performed on the electrochemical decomposition of organic compounds with diamond anode.This study shows a complete removal of refractory COD, BOD, ammonical nitrogen and TSS from bulk drug effluent during the electrochemical oxidation treatment process.