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Elucidating the role of MKK4 in neuronal apoptosis

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Brain injury and neurological conditions are often associated with the excessive loss of neurones through apoptosis. In the brain, apoptosis is triggered by the activation of the c-Jun N-terminal protein kinase (JNK) signalling pathway by two mitogen-activated protein kinases (MAPKs): MKK4 and MKK7. While both proteins activate JNK in response to various extracellular stimuli, the biological functions of MKK4 and MKK7 in neuronal cell death remain to be identified. To advance our knowledge, I have developed two novel models of neuronal apoptosis using primary cultures of cortical neurones (MECN) and cerebellar granule neurones (CGN) in which MKK4 expression can be deleted. The absence of MKK4 significantly impedes stress-induced caspase-3 activation in both cell types and partially protects neurones against stress-induced death and apoptosis. Furthermore, the loss of MKK4 leads to the inhibition of JNK3 activation following stress, and causes a marked decrease in the expression of c-Jun, a major target of JNK. This study suggests that MKK4 mediates stress-induced apoptosis in neurones through the activation of the JNK3/c-Jun pathway.

Product Specifications
SKU :COC37499
AuthorAuriane Destrument
LanguageEnglish
BindingPaperback
Number of Pages144
Publishing Year2010-06-01T00:00:00.000
ISBN978-3838336862
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00