Starting day one of the existence of human beings people with disabilities have been leading a life of challenge, difficulty, turmoil and so on as the list is long unto denial of the right to life. However, there were and are persons with disabilities who had and have changed the world in their positive influence. To mention few of these personalities we find like Albert Einstein, Aristotle, Hellen Keller, Socrates, Alexander Grahambel, Alferd Nobel, Franklin D. Rooselvet, Stephen Hawking the list goes on. This book therefore, analyses about the historical account of people with disabilities, society's reaction towards the disability of people with disabilities,reaction of persons with disabilities towards their disabilities, challenges of life of people with disabilities,achievements of people with disabilities in the world, community participation of people with disabilities and factors that make people with disabilities be successful. Finally, life histories of four Ethiopian successful persons with disabilities was presented with its scientific discussion. Indeed, this book is aimed at serving the interest of people with and without disabilities.