The distillation has numerous advantages but it has also a drawback, namely its significant energy requirement. In order to reduce the energy consumption of the distillation systems energy integration can be applied. During the process design it is important to select the best applicable energy integration for the distillation system in the case of the given separation task. In the last decades environmental consciousness and controllability are also important criteria of the process design. The primary motivation of this book is to elaborate a complex process design methodology that evaluates the distillation systems based on exergetic, economic, and greenhouse gas emission aspects. The aim of the methodology is to determine how these three features should be applied in process design to obtain information about the accuracy of the design alternatives. The methodology is tested and demonstrated on three different energy-integrated distillation systems. The secondary motivation is to investigate the controllability features of the these distillation systems and to elaborate an easy applicable controllability analysis method in order to select the easiest controllable one.