Malaria is a mosquito-borne infectious disease of humans. The World Health Organization has estimated that in 2010, there were 219 million documented cases of malaria.That year, between 660,000 and 1.2 million people died from the disease malaria. Enteric coatings allow the drug delivery system to pass through the stomach intact and dissolve upon reaching the intestine. Chloroquine is very cheap and, until recently, was very effective and the first choice for malaria treatment. Side effects include gastrointestinal problems such as stomach ache, itch, headache and blurred vision. Enteric coating prevent the drug release in the stomach preventing gastric irritation and mask the bitter taste of drug. so It has long been used in the treatment or prevention of malaria.