This is the fourth edition of the book, continuing my personal determination to create new and original books from the entrepreneur and entrepreneur activities area. The entrepreneurship is dynamic moving force. In the last years this branch has fast development in the model of understanding of the entrepreneurship itself and what one entrepreneur present. In this work (book) every reader can find new contents for the entrepreneurship, creativity and innovation with more and more importance for the entrepreneurs. In the same time I am trying to put attention to the changes with more preciseness in the working in this book. The entrepreneurs are the moving forces that create changes constantly.During the creation of this book I was leaded by the basic principle – to create a book to explain the modern entrepreneurship process and the characteristic of the entrepreneur of the 21st century through the following phases: emphasizing the importance of the creativity and innovation of the entrepreneurs, preparation activities before start a new business and entrepreneur of the 21st century.