Infection with HIV has different epidemiological and clinical profile. But there is no enough information that shows patient profile throughout the country. There for to assess the epidemiological, immunological and clinical future of HIV positive patients, this follow up study was conducted in Bishoftu Hospital, Ethiopia. The data source of this study was patient medical records that have enrolled in care and treatment between Septmber 2007 and November 2009. A Total of 600 patients’ medical record was selected and reviewed using systemic sampling technique. The study found out that young individuals, females, urban dwellers, low educated and unemployed were the predominant groups enrolled for treatment. Most of the patients were showed clinical sign and symptoms during enrollment and their CD4 also low but it showed increment gradually. Therefore understanding of patient epidemiological, clinical and immunological future will help to design effective prevention and intervention strategies for HIV infection.