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Epigenetic Regulation of Asthma: Role of Stat3, Socs3 and IL-6


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  • Product Description

Stat3, Socs3 and cytokines play an integral role in coordination and persistence of inflammation. However, a clear understanding of the role played by the Stat3/IL-6 and Socs3 pathway in airway inflammation is lacking. We report the alteration in the status of expression and activation of Stat3 by Ovalbumin, and establish its relationship with Socs3 and IL-6 in the lungs of mice with eosinophilic pulmonary inflammation and airway hyper responsiveness. As IL-6 regulates the activity of DNA methyltransferases, we hypothesize that asthma is fallout of epigenetic alteration in Socs3. Here, the status of CpG methylation and histone acetylation in the Socs3 promoter of asthmatic lung was studied, as was the role of IL-6 in altering these parameters.

Product Specifications
SKU :COC86987
AuthorVani Mishra and Rohit K. Mishra
Number of Pages104
Publishing Year2013-03-12T00:00:00.000
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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