The assurance of the quality and the reliability of the pharmaceutical products together with their careful control are a moral obligation arising from the humanism towards the sick.Consequently the manufacture and the control of drugs is a very responsible task and needs substantial knowledge of science.Drug analysis is carried by analytical methods which further classified as Chemical and Instrumental Analytical methods. Although chemical methods are cheap, but instrumental methods are very fast and accurate.A search of literature reveals that there are very few methods available for the determination of Ofloxacin in combination with Ornidazole. Various methods reported are basically HPLC/RP-HPLC etc. These methods are very expensive and cannot be afforded by small scale industries.In the present study we attempted to develop a simple, rapid, economical and selective method for the estimation of Ofloxacin and Ornidazole in combined dosage tablet form using U.V.-Vis. Spectrophotometer.The spectrophotometric estimation of Ornidazole and Ofloxacin was statistically evaluated and was found to be very accurate. proposed method can be employed for routine analysis in Quality Control.