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Ethnopharmacological profile of garden rue: role in inflammation


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The book describes a protocol to evaluate anti-inflammatory activity in popular animal models along with biochemical and molecular pharmacological investigations. The present work evaluated the anti-inflammatory and antioxidant activity of the methanol extract of Ruta graveolens leaves (RG–M) in various in vivo and in vitro models. For the anti-inflammatory activity evaluation, RG-M was administered by the oral route (p.o.) in carrageenan–induced paw edema model and by the intraperitoneal route (i.p.) in exudative inflammation model. In vitro inhibition of cyclooxygenase and lipoxygenase enzymes was also investigated. In vitro antioxidant activity was also evaluated. Endogenous antioxidant status was further screened by ferric reducing ability of plasma model. The extract showed maximum inhibition of carrageenan – induced edema and in exudative inflammation model, significant reduction in leukocyte migration and protein exudation were observed. RG–M also revealed inhibition of COX–1 and COX–2 as well as 5–LOX. Antioxidant activity was found to be significant along with improved endogenous antioxidant status.

Product Specifications
SKU :COC60507
AuthorManjir Sarma Kataki,Bibhuti Bhusan Kakoti and Ananya Rajkumari
Number of Pages76
Publishing Year11.09.2014
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00