The cow urine therapy is capable of curing several curable and incurable diseases. Cow’s urine also called Gomutra is recommended as a healing aid in Ayurveda. A person falls ill when there is deficiency (alteration) of the substances inside the body. The cow urine contains those substances, which are present in the human body. Therefore, consumption of cow urine maintains the balance of these substances and cures incurable diseases. In the present study we have found that cow urine consumption significantly reduced the elevated lipid profiles in human and animals. It is also found that cow urine significantly reduced the body weight of obese animals. Hence it was proved to be the natural medicine for the treatment of hyperlipidemia and obesity.