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Examples of “Infinite Affinity” for Applications in Bioconjugations


Marketed By :  VDM Verlag Dr. Müller   Sold By :  Kamal Books International  
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  • Product Description

Bioconjugation is the process of coupling two biologically relevant molecules together with a covalent linkage. Almost all bioconjugations are facilitated with linkers, which are generally small organic molecules. These techniques have long provided a plethora of biologically useful reagents in various analytical applications such as tagging mechanisms, like the metal chelate mass/affinity tags, fluorescent markers for flow cytometry and microscopy, as well as therapeutic applications such as targeted drug delivery, nuclear magnetic imaging and nuclear medicine applications in oncology. These linkers are highly selective, stable in solution, not susceptible to non-specific binding in biological environment, with stable isolatable intermediates. They include small molecules, macrocyclic metal chelates and small cyclic peptides. These small linkers and cyclic peptides provide novel small molecule bioconjugation chemistries that use the thiol ester carbonyl to specifically react towards a lysine under biological conditions or through formation of disulfides. These new linkers are thought of such that they would all serve as infinite affinity binders.

Product Specifications
SKU :COC22504
Authorsaeed khazaie
Number of Pages196
Publishing Year9/17/2010
Edition1 st
Book TypeOrganic chemistry
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-28 00:00:00