In spite of numerous socioeconomic problems in Sub-Saharan Africa (SSA), there has been an increasing growth of Internet connectivity, and much business activity has arisen to take advantage of this technology; the dark continent shines with new opportunities that have arisen in the information age. This book describes an investigation of experts’ assessments of the pertinent factors affecting e-business in SSA from the dual perspective of national infrastructure and culture. From a national infrastructure perspective, experts respond regarding the effects of national policies on information and communication technology (ICT) and e-business, ICT infrastructure, national governance institutions, and commercial infrastructure. From the cultural perspective, they respond about ICT transfer implementation, power distance, uncertainty avoidance, and technology culturation. This study of e-business in urban small and medium-sized enterprises in SSA is relevant to business practitioners, government officials, officials of nongovernmental organizations, and academic researchers.