Book describes the system model to analyze human blood tissue matrix. It is well known that the human blood is a multivariate system consisting around 120 major constituents. Glucose is one such constituent, which provides instant energy for cell metabolism, and the imbalance in glucose, leads to various health problems. The book emphasizes the non-invasive blood glucose measuring technique. The working principles of different radiation based techniques of glucometers are described in full detail while the Near Infrared based technique is emphases . Also the multivariate system model used to quantify the blood glucose is discussed in details. The simulation spectrums for the human blood were generated using oscillator's technique to compute the calibration and prediction error in the multivariate model.