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Exploring the Role of miRNAs in Human Cancer

 

Marketed By :  Scholars' Press   Sold By :  Kamal Books International  
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  • Product Description
 

Unraveling the role of microRNAs in cancer has gained growing interest in the last few years. In this study, we identified miR-215 as a potential prognostic biomarker and miR-129 as a potential tumor suppressor and a novel therapeutic target in colorectal cancer. We showed that miR-215 levels were significantly decreased in tumors compared with corresponding normal tissues in patients diagnosed with stage II or stage III colorectal cancer. Furthermore, we described a novel mechanism mediated by miR-129 to trigger apoptosis by suppressing a key anti-apoptotic protein, BCL2. The expression of miR-129 was significantly and progressively down regulated in colorectal cancer tissue specimens compared with the adenomas and normal control samples. More importantly, we demonstrated that miR-129 increased the cytotoxic effect of 5- fluorouracil, in vitro and in vivo. We expect that our findings will provide a better insight into the role of microRNAs in cancer and will allow us to carry these molecules into clinical application.

Product Specifications
SKU :COC64053
AuthorMihriban Karaayvaz
LanguageEnglish
BindingPaperback
Number of Pages164
Publishing Year2013-11-24T00:00:00.000
ISBN9783639703993
Edition1 st
Book TypeEconomics
Country of ManufactureIndia
Product BrandScholars' Press
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-08 00:00:00