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Fabrication of Nanoparticles of Gemcitabine and its Derivatives

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Gemcitabine is a nucleoside analogue, used in various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with gemcitabine include its short half-life and highly hydrophilic nature. The objectives of this investigation were to synthesize lipophilic derivative of gemcitabine, evaluate the physiochemical properties, entrapment efficiency, in vitro release, cytotoxicity, and cellular uptake of nanoparticulate formulations containing gemcitabine and stearoyl gemcitabine. We successfully prepared a formulation providing dual protection of gemcitabine against chemical decomposition from plasma catabolism and improve metabolic stability, first by covalently linking the amino group of gemcitabine to a long fatty chain, and then by encapsulating this lipophilic derivative in the formulations. PLGA nanoparticles can act as carriers for both lipophilic and hydrophilic drugs.

Product Specifications
SKU :COC60483
AuthorAmit Gupta,Mithun Singh Rajput and Manish K Chourasia
LanguageEnglish
BindingPaperback
Number of Pages100
Publishing Year19.12.2014
ISBN9783659666131
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00