Adherence to ART is the most powerful predictor of survival for PLWHA; several factors have been associated with ART adherence such as patient characteristics, socioeconomic factors, treatment regimen, disease characteristics, patient-care provider relationship, and clinical settings. Therefore, the purpose of this study was to identify and to assess factors influencing ART adherence in the different dimension like Socio-economic effects, adherence information, and level of adherence behaviour among patients who take ARV drugs in Fital Health Center in Yaya Gulale Woreda. In the result of the study shows that that the more disadvantageous part of the population that is female and youth are exposed to HIV. In addition, awareness creation program is very essential for the people about the benefit of ARV drug and the benefit of the adherence to the drug for life long time to live long with HIV. Factors like too busy, lack of awareness on the benefit of adherence on medication that prescribed by health care providers that influence the adherent level of most respondents. So, patients have to give due attention for the medication because this is the way they sustain their life.