The increasing rural poverty has motivated the fisher folk community to develop coping strategies to mitigate the accompanied risks and challenges. One such strategy is establishment of fisher folk projects. However, though an economic and survival strategy, it has associated challenges such as substance abuse among the projects’ stakeholders. Although there exists a certain body of knowledge regarding substance abuse among different communities, studies on how substance abuse influences community projects are limited. This study is aimed to establish factors influencing substance abuse among fisher folk projects in Homa-Bay County, Mbita Constituency.The study adopted a descriptive survey research design. The total target population was 1,604 stakeholders of fisher folk projects in Mbita Constituency. The population was stratified into 4 categories along which projects were formed. A sample size of 310 projects’ stakeholders was selected from the target population. Data was collected through administration of questionnaires and Schedule interviews. Descriptive statistics was used to analyze data collected using SPSS package.