Fast Dissolving Films- A Novel Approach for Delivery of Domperidone

Fast Dissolving Films- A Novel Approach for Delivery of Domperidone


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The book describes the preparation and evaluation of orally fast dissolving film of Domperidone- an anti emetic drug. As Domperidone possess very less water solubility, preparation of rapidly dissolving film is a challenge. Hence, in order to increase the solubility, solid dispersion approach is utilized and it is prepared using beta- cyclodextrin as a carrier. Solid dispersion are prepared in various molar ratio of Drug: Carrier and evaluated. Based on evaluation, the optimized solid dispersion is selected and utilized further for the preparation of films. Suitable film forming polymer was selected from the available polymers i.e. HPMC E3 LV, HPMC E5 LV, HPMC E15 LV and pullulan. PUllulan was found to be suitable for preparation of film. Films are prepared using pullulan and PEG-400 by solvent casting method and evaluated. Factorial design was applied in order to decide the optimized formulation and it was then compared with the films prepared with plain Domperidone. Results showed that films prepared using solid dispersion were better than the films prepared using plain Domperidone. Hence, fast dissolving film of Domperidone was successfully prepared.

Product Specifications
SKU :COC31262
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31
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