Plants, the beauty of nature have been the basis of treating human ailments. The current accepted modern medicine has gradually developed over the years and no doubt is the gift of God in the sense of traditional knowledge about different medicinal plants. However, what are needed are rapid screening techniques, structure base design and combinatorial chemistry for drug development under new innovations which will share the profit of products derived from indigenous plants. There is less known information about Ficus exasperata Vahl., and Cleome ciliata Schmach and Thonn. However, author in this book presents comprehensive information about traditional uses, biological and phytochemical investigation of Ficus exasperata Vahl., and Cleome ciliata Schmach and Thonn.