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Fluoroquinolones- Lipids membranes interactions: Biophysical studies

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Probing Fluoroquinolones-lipid interactions at the molecular level represents an important challenge in both membrane biophysics and pharmaceutical research. As the pharmacological target of these drugs is intracellular, they must pass across the bacterial membranes. Likewise, Fluoroquinolones enter eukaryotic cells, which imply their ability of interacting with lipids membranes. This book, therefore, characterize the effect of two closely related drugs ciprofloxacin CIP and moxifloxacin MXF on physicochemical properties of the major phospholipids that are mimicking the prokaryotic and the eukaryotic lipid membranes, respectively. Several models of lipid membranes and biophysical methods (Atomic force microscopy, Langmuir-Blodgett technique, as well as fluorescence, infra-red, nuclear magnetic resonance spectroscopies) are described. Our data suggest that the first step in the interaction of CIP with lipid membranes relates to its binding to the headgroups of phospholipids and that MXF is located in a more hydrophobic environment of the membranes. Our work may help in shedding more light on the role played by lipids in the drugs transport, and should be useful to young researchers.

Product Specifications
SKU :COC95131
AuthorHayet Bensikaddour
LanguageEnglish
BindingPaperback
Number of Pages180
Publishing Year2011-09-22T00:00:00.000
ISBN978-3846509333
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00