A survey study on the folk medicinal uses with recipes and ethnomedicinal uses of sixty medicinal plants was carried out in three main districts i.e. Umerkot, Daudu and Jamshoro Sindh, Pakistan. Since long time the people of this area have been using medicinal plants and their different parts for the cure of a variety of illnesses. The knowledge about the traditional uses of these medicinal plants and their folk recipes remained untouched for scientific exploration by the pharmacognosists, ethnobotanists, ethnopharmacologists, pharmacists and chemists. The folk uses and traditional recipes of sixty medicinal plants are therefore acknowledged which are typically used in the healing of many health problems and diseases by the people of these three districts of Sindh, Pakistan. Through this study, the medicinal plants are documented on the basis of their folk recipes and ethnomedicinal uses to demonstrate their efficacy to treat various diseases of humans and animals.