Ketorolac tromethmaine is a Nonsteroidal anti-inflammatory drug. It is used as Antipyretic, anti-inflammatory and analgesic. It is indicated Ketorolac tromethamine ophthalmic solution is indicated for the temporary relief of ocular itching due to seasonal allergic conjunctivitis & for the treatment of postoperative inflammation. Preservative in high concentration hazardous to Ocular cell. Therefore, the aim of the present study was to formulate a formulation for ketorolac tromethmine (0.5%) ophthalmic solution using different concentration of Benzalkonium chloride as preservative. While reducing the concentration of Benzalkonium chloride it must be keep in mind that added quantity of preservative must meet compendial requirement of Preservative Efficacy Testing as per United state Pharmacopoeia (USP).The present research work is also planned to provide the data about the selection of suitable primary packaging material for Ketorolac tromethmine (0.5%) to achieve the better stability during the shelf life of the product.