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Formulation and Evaluation of Fast Dissolving Sublingual Tablet

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic

Product Specifications
SKU :COC60499
AuthorBrahmdutta Raval,Naisarg Pujara and Vicky Ranpura
LanguageEnglish
BindingPaperback
Number of Pages116
Publishing Year28.08.2014
ISBN9783659595363
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00
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