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Formulation and Evaluation of Floating In Situ Gel of Levetiracetam


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  • Product Description

The aim of this study was to develop a new intra-gastric ?oating in situ gelling system for controlled delivery of levetiracetam for the treatment of partial onset seizures.High dose of levetiracetam (750 to 1000 mg) is di?cult to incorporate in ?oating tablets but can easily be given in liquid dosage form. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which drug and calcium carbonate were added. A 32 full factorial design was used for optimization. The concentrations of sodium alginate (X1) and calcium carbonate (X2) were selected as the independent variables.The amount of the drug released after 1 h (Q1) and 6 h (Q6) and 12 h (Q12), viscosity and Floating lag time of the liquid formulation were selected as the dependent variables. The studies indicate that the formulation was effective in providing in vitro release for extended time up to 12 hrs and also convenient for geriatric and paediatric patient and increase drug residency to the GIT.

Product Specifications
SKU :COC31121
AuthorMiteshkumar Patel,Kanu Patel and Natvarlal Patel
Number of Pages132
Publishing Year6/14/2012
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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