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Formulation and Evaluation of Ion Exchange Resin Based Soluble Ocusert

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

In recent years scientific and technological advances have been made in development of ocular controlled drug delivery system to overcome physiological adversities of conventional dosage form. The present investigation was focused to prepare resinate of moxifloxacin and ion exchange resign to increase the residence time and decrease the solubility of drug in ocular site and incorporated in ocular insert. Ocular insert was prepared by solvent casting method. Nine formulations of OCDDS were prepared with different concentration of polymer (HPMC, MC, and PVA). Prepared formulation was subjected to physicochemical evaluation test,In vitro release, In vivo release and accelerated stability study test. In vivo release of formulation BRF6 was shown 98.87 % at the end of 12th hrs. In vitro release of all the formulation was computed with release kinetic model to predict release rate.suggested that all formulation was followed anomalous diffusion mechanism. Optimized formulation (BRF6) was subjected to antimicrobial test and sterility test. Result clearly showed it was passed. Accelerated stability study indicated optimized formulation was stable for longer period of time.

Product Specifications
SKU :COC31624
AuthorRamesh Parmar and H. M. Tank
LanguageEnglish
BindingPaperback
Number of Pages84
Publishing Year11/27/2012
ISBN978-3843363372
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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