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Formulation Of Dual Release Dosage Form By Mixed Solvency Concept


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The main objective of present study was to explore mixed solvency concept in preparation of dual release tablet dosage form of indomethacin. The aim is to make water a strong solvent for the indomethacin for preparation of solid dispersion of drug using mixed solvency concept by use of safe solubilizers (niaicnamide, sodium benzoate and sodium citrate) and preclude the use of toxic organic solvents used in solvent evaporation technique. Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) It is indicated for moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis. The objective of the present research work is to develop once a day dual release tablet dosage form of the drug, to overcome gastric irritation caused by repeated use of NSAID in short duration of time. The immediate release is rapidly absorbed from the stomach to provide a bolus dose of active agent. The sustained release indomethacin is gradually released over time to maintain the blood level at effective concentrations for long period of time.

Product Specifications
SKU :COC31187
AuthorDev Kumar Bhalse and R.K. Maheshwari
Number of Pages136
Publishing Year2012-01-10T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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