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Formulation Strategies for dissolution enhancement of insoluble drugs

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Dissolution is important parameter to achieve desired concentration of drug in systemic circulation for elicit pharmacological response. The formulation of poorly soluble drugs has been the subjects of much research, as approximately 40% of new chemical entities develop in pharmaceutical industries are insoluble in nature. In the present investigation drugs which are practically insoluble in gastric fluid and having high permeability through stomach were selected. The rational for selecting such type was “Drugs which are only permeable through stomach but due to its solubility limitation in gastric fluid they can not enter in to systemic circulation, further more gastric empting time is ranging form 30 mins to 2 hrs after this time drugs enter in to small intestine where they can soluble but can not permeable through its membrane due to its permeation limitation”. To improve dissolution of such drugs in stomach are challenging and rational. Attempts were made to prepare formulations which would dissolved completely within 30 minutes or retain in stomach for more than 2 hrs if drugs can not soluble in 2 hrs even after addition of solubilising enhancing excipients.

Product Specifications
SKU :COC94508
AuthorRajnikant Patel,Madhabhai Patel and Natvarlal Patel
LanguageEnglish
BindingPaperback
Number of Pages180
Publishing Year2011-03-10T00:00:00.000
ISBN978-3844310696
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00