This book emphasizes on a Field Programmable Gate Array (FPGA) Implementation of Fuzzy PD and PID Controller for biomedical application. A novel approach aims to identify and design a simple robust Fuzzy (PD and PID) Controller system with minimum number of fuzzy rules to deliver insulin from pumps as a single injection process for the diabetic patients. This controller is an automatic feedback control system in which the patient’s blood glucose level is monitored from non-invasive Photo plethysmogram of a pulse oximeter (Photoglucometer) and insulin is infused with the change in the glucose level of the diabetic patient. This work was carried out in three phases like phase –I VLSI Design and simulation of Fuzzy PD controller were performed and analyzed. From the VLSI Simulation results FPGA Model was synthesized in the phase-II. During phase –III performance of the fuzzy PD Controller was evaluated. VLSI fuzzy system was simulated and analyzed then FPGA module was synthesized and implemented using VHDL.A part of this work was sponsored by IEEE Inc., (U.S.A) under scheme IEEE Student Enterprise Award 2007-2008 title FPGA Model of Fuzzy PD Controller for Insulin Pumps In Diabetes.