There are several critical factors reshaping energy consumption patterns across the globe. The Caribbean region is not exempted from these sweeping movements. The small and fragile economies are unable to cope with increasing crude oil fuel costs and currently, many within the region are in search of alternative energy arrangements. Among the many potential options, natural gas has been considered by some experts as a worthwhile alternative. Further, methanol has been proposed as a possible means of transporting gas across the region. Similarly, biofuels also present a key potential energy source for the region; its topography, biodiversity and long agricultural history make it well poised to capitalize on this option. This work examines the use of methanol/biofuel blends as a viable fuel alternative for the Caribbean region. The work presents both technical and economic analyses of an alternative power generation value chain, taking into consideration the unique context and challenges of the Caribbean region. The findings point to a feasible, flexible approach with the potential to strengthen the regional economy and bolster its efforts toward sustainable energy development.