Functional characterization of lipid binding of P122 START domain


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  • Product Description

P122RhoGAP/DLC-1 is a novel dual functional regulator of cell shape and motility and an antioncogenic gene product. Functions of p122RhoGAP/DLC-1 relate not only with cytoskeletal regulation but also subtle tuning of Ca2+ / phosphoinositide signaling. These are based on the intramolecular structure, especially domain structure of the molecule. I aim to explore the functional characterization of the START domain, a candidate domain for lipid binding and / or transfer , of p122RhoGAP/DLC-1. The process of tumor progression is still poorly understood. Mechanism for regulation of cell proliferation,cell motility and invasiveness are important for the development of cancer and potential target for cancer therapy. P122RhoGAP/DLC-1 has some functional domains such as RhoGTPase activating protein domain, which has been hypothesized to be the basis of its tumor suppressive actions and a steroidigenic acute regulatory(StAR) related lipid transfer START domain, both located in its C-terminal domain. The lipid binding function is still unknown in the case of p122RhoGAP/DLC-1.

Product Specifications
SKU :COC77514
AuthorGouri Rani Banik
Number of Pages60
Publishing Year2014-07-08T00:00:00.000
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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