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Functional characterization of prostate tumour cell lines

 

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  • Product Description
 

In this work a siRNA screen of around 1500 genes was performed using four different cell lines (VCaP, LAPC-4, RWPE-1, MDA-PCa 2b). Therefore a new method called living cell array was used in order to obtain information about the process of androgenesis in prostate tumour cell lines. This method is based on the principal of the reverse transfection [Sabatini, 2001], where the cells are added to the plate after the transfection reagent has been spotted. The cells on the living cell array were set under stress by the addition of androgen ablated media while the proliferation and apoptosis was measured. Knocked-out genes that caused a significant increase or decrease of the proliferation/apoptosis ratio were collected. It is expected that some of these genes influence the pathway of the androgen receptor and therefore might be relevant for the development of new inhibitors.

Product Specifications
SKU :COC99404
AuthorPeggy Reich
LanguageEnglish
BindingPaperback
Number of Pages72
Publishing Year2011-07-20T00:00:00.000
ISBN978-3639358919
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandNot defined
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00