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Functionally Modified Alginate Particles for Oral Delivery of NSAIDs


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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Rs. 3,718

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  • Product Description

Calcium alginate microparticles alone are not suitable for sustained oral drug delivery applications. They rapidly disintegrate in weakly alkaline conditions of intestinal fluid and liberate their content. Herein, sodium alginate was chemically modified to circumvent this problem. The oxidation of the polymer was controlled such that oxidized alginate could form microparticles by ionic gelation with divalent Ca+2 ions. Oxidized polymer was characterized by measuring the aldehyde content, degree of oxidation and by FTIR spectroscopy. Spherical oxidized alginate particles were able to control the release of flurbiprofen in simulated gastrointestinal milieu for longer durations. The drug release correlated with the swelling nature of particles. In addition, ibuprofen-loaded Ca-alginate particles reinforced with cationic polyelectrolytes exhibited sustained drug release properties. The percentage drug release was very small in gastric fluid and thus could avoid gastric side effects associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). This book was written for the benefits of the research scholars and scientists working in the field of drug delivery research.

Product Specifications
SKU :COC76808
Number of Pages96
Publishing Year2014-08-07T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00