The present work deals with the antisecretory and gastroprotective effect of selenomethionine in swiss albino rat system by using 1. 4 hour Pylorus ligation model for antisecretory activity using the following pathophysiological and biochemical parameters in gastric juice and gastric mucosa a) Ulcer index measurement of the glandular portion of the stomach, b) Measurement of volume, pH, free and total acidity, peptic activity, DNA content of the gatsric juice and c) Total protein, carbohydrate estimation in gastric juice and gastric mucosa, 2. ethanol induced gastric ulcer model using a)Ulcer index measurement,b) Gastric wall mucous content estimation and c)Lipid peroxide level estimation, 3. stress induced ulcer model using a) Measurement of ulcer index, b)Estimation of gastric wall mucus content and 4. Aspirin induced gastric ulcer model of ulcer index measurement. Antiulcer and cytoprotective effect of Selenomethionine and reference drug Cemetidine in rats are studied in the above validated gastric ulcer models after a desired period of drug administration. This work works at the development of a novel gastroprotective molecule.