A number of oral controlled release systems have been developed to improve the delivery of drugs to the systemic circulation. Although such systems can control precisely and predictably the drug release rate for extended period of time, even over a number of days, they do not always perform satisfactorily if they pass through the drug absorption site e.g. the small intestine, before the release of loaded drug is complete. Thus, attention must be given to prolong the residence time of the system to achieve complete drug release in GI tract as well as to modulate the drug release rate as predicted by the system in order to obtain an ideal oral control release system. The present study is undertaken for the development of gastroretentive technology which will deliver the antibiotic at predetermined rate to achieve the local concentration enough to act as antibacterial against H.Pylori. This technology ensures the maximum utilization of the drug with minimum side effects, maximum patient compliance and reduced antibiotic resistance by the bacterium.