Biological structure of female and cultural construct of gender injustice, women and girl-children are much more vulnerable to health risks such as HIV-AIDS, anaemia, PEM, reproductive tract infections etc. Their domestic and economic burdens, lack of decision making capacity, social stigma, altogether hamper easy accessibility to health delivery, both preventive and curative. The blow of dreaded diseases such as HIV-AIDS and social injustice on the fair-sex is very unfair. In-depth study on the gender dimension of HIV-AIDS in one of the most HIV-AIDS affected state of India throws light on the issue ‘Gender and HIV-AIDS’. This concise capsule is a rare ingredient of the synergistic chemistry of personalities of different backgrounds synthesizing specially for social scientists, students, scholars, health professionals and general readers.