This book explores Ghanaian drug-using youth’s perceptions of how stressful life events and social support influence their drug use behaviour. Given that previous research examining the influence of stressful life events and perceived social support on youth’s drug use have preponderantly been conducted in Western cultures, little is known about the influence of stressful life events and perceived social support on the drug use of non-Western youth, particularly African youth. Thus, this book has been written using data collected from drug-using youth resident in a rural community in Ghana, West Africa. Findings are discussed in the light of relevant theories and related studies. Implications for drug use interventions and health praxis, and future research on drug use are also discussed in this book.