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Glutamic Acid As Antineoplastic Agent

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The investigation on glutamic acid analogs as possible antineoplastic agents started in the laboratories in the seventies. In continuation of this line of work several substituted amines were prepared and evaluated biologically. The main focus of this reaction work was to synthesize analogs of glutamic acid and look for their better antineoplastic activity. The structure of the synthesized compounds were confirmed and characterized with the help of IR, 1H-NMR, 13C-NMR, Mass spectra and elemental analysis. For the docking we have taken the protein Histone Deacetylase (HDAC) and identified the glutamic acid analogs that were used against Cancer. Here, out of 10 glutamic acid analogs, 6 better active analogs energy value was determined. The synthesized analogs were evaluated for their potential antineoplastic activity both in-vitro and in-vivo. The in-vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adeno carcinoma (HT-29) and human kidney carcinoma (A-498). The in-vivo activity was performed in female Swiss Albino mice against Ehrlich Ascites Carcinoma (EAC).

Product Specifications
SKU :COC76824
AuthorSatyajit Dutta,Supratim Ray and K. Nagarajan
LanguageEnglish
BindingPaperback
Number of Pages128
Publishing Year2014-11-21T00:00:00.000
ISBN9783659640124
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00