A green chemical synthetic protocol has been developed for the rapid parallel synthesis of a library of biologically potential 2-amino-4-arylthiazoles, employing water as a solvent under microwave irradiation (MWI). This novel process yields the target NCE’s in very short time, good yield and purity. The judicious use of water as green solvent is attractive and cost effective & makes the process eco-friendly. Besides the general discussion on the biology and synthesis of 2-aminothiazoles, a short review on MWI and use of water as a green solvent is also included. The target NCE’s bear good antifungal and antibacterial potential.