This book presents an expert’s view of the hand exoskeleton robotic systems. A systematic and thorough analysis of the subject matter helps to identify research lacks in this area. Design of such systems demands careful investigation of the associated requirements. Results collected from series of experiments on human hand of variable sizes using various sensory instrumentation have been discussed in the book. These requirements can then be mapped directly on the mechanical design of the system. The derived design requirements will lead to further research on developing optimized hand exoskeleton systems. Such devices will hopefully become a reality in our society in the near future to provide more sophisticated interaction with real and virtual environments in haptics, VR and rehabilitation.