A qualitative research was deployed to explore the implication of health seeking behavior on adherence among Antiretroviral Therapy (ART) users in Zewditu Memorial Hospital. Study participants were selected purposely based on years of experience in attending ART in the Hospital and their self expressive ability. Among the major findings of the study, threat perception and perceived benefits has played the major role in influencing antiretroviral therapy adherence. Moreover, self efficacy, cues to actions, and perceived barriers to antiretroviral therapy have their contribution for adherence though it is less weighted as compared to threat perception and perceived benefits. The study forwarded integrating family and relatives'' involvement, development of ART users self esteem, education on misconceptions and coping mechanisms for stigma and discrimination, psychosocial support, and integrating the available care and support programs with the ART program as an essential component for adherence. Adherence is subject to perceived susceptibility, perceived benefits, perceived barriers, cues to actions and self efficacy of individuals who are taking ART.